Everton are without star striker Nikica Jelavic after he collided with a post in Monday’s game against Newcastle. Swansea have defensive problems to contend with as Chico is suspended and Kyle Bartley, Gary Monk and Neil Taylor are all injured.
Oscar is expected to be fit following his wonderful first start against Juventus that saw him score twice in the Champions League but also get a nasty kick from Leonardo Bonucci.
Summer signing Christian Benteke will make his first start for Villa after coming off the bench to score against Swansea last weekend. Southampton could also hand a first start to record signing Gaston Ramirez.
Peter Odemwingie is suspended for West Brom following his idiotic red card against Fulham, while Reading will once again be without goalkeeper Adam Federici so Alex McCarthy will stand in.
Andy Carroll has returned to training but is not ready to feature for West Ham. Sunderland are also deprived of an England international as Adam Johnson has a thigh problem.
Bryan Ruiz and Mladen Petric are both fit and vying for the right to start alongside Dimitar Berbatov in the Fulham attack.
Liverpool will make widespread changes after putting out an inexperienced side to face Young Boys in the Europa League. Wayne Rooney has not made it back in time to feature for United while Ashley Young is another absentee.
Cheick Tiote could make his return from a calf injury to feature for Newcastle, who are also strengthened by the return of Papiss Cisse after he missed the Europa League game against Maritimo due to injury.
Brad Friedel will return in goal after Hugo Lloris was preferred in the Europea League. Meanwhile, QPR have been beset by injuries with Andy Johnson out for most of the season and Fabio and Anton Ferdinand both ruled out.
Samir Nasri misses the game against his former side but Sergio Aguero is fit to return in attack for City. Arsenal are again without goalkeeper Wojciech Szczesny due to injury.