Arsenal host Chelsea in a London derby
Captain Thomas Vermaelen returns for Arsenal but all eyes will be on John Terry, who is available as he still ponders whether to appeal against his four-game ban for racially abusing Anton Ferdinand.
Everton will recall their senior players after being knocked out of the Capital One Cup by Leeds in midweek. Southampton are missing midfielder Jack Cork, who will be out for around six weeks after injuring his knee.
City will ring the changes after suffering at the hands of Aston Villa in midweek and Samir Nasri could return to the side after regaining full fitness. Jack Rodwell misses out though.
Liverpool hope Daniel Agger will recover from a bruised bone but Jonjo Shelvey is suspended and Fabio Borini only has a 50 per cent chance of playing.
Jason Roberts has recovered from a calf injury and could feature for the home side, while Newcastle will hope Papiss Cisse is on form again after grabbing his first goal of the season in a League Cup defeat to Manchester United.
Stoke are at full strength but Michael Owen will have to do with a place on the bench again. Swansea welcome Chico and Nathan Dyer back from suspension.
Sunderland winger Adam Johnson will undergo a late fitness test but captain Lee Cattermole starts a three-game ban. Wigan are missing Antolin Alcaraz and Franco Di Santo.
United are waiting on news of an ankle injury to Antonio Valencia but Wayne Rooney and Robin van Persie could start together for the first time. Spurs will bring Brad Friedel back into the starting XI.
Villa are without Stephen Ireland due to a wrist injury but winger Brett Holman will return from a knee injury for the Midlands derby.
QPR are missing four defenders with Anton Ferdinand, Jose Bosingwa, Armand Traore and Fabio all out. West Ham are still without Andy Carroll.