Champions League – Team news: Evra missing
The French left-back has a hamstring injury, which he picked up in the 4-0 Premier League win against West Bromwich Albion.
He took part in limited training at the club’s Carrington base on Monday, but Alex Ferguson decided not to risk aggravating the condition.
Ferguson said: “It’s too big a risk with a hamstring injury. He should be OK for Saturday.”
United travel to Goodison Park to face Everton in the Premier League’s lunch-time kick-off.
Cristiano Ronaldo may also be given an evening off as he continues his return following ankle surgery in the summer.
Ferguson’s side have four points from their first two games after drawing at home to Villarreal and beating Aalborg away.
Villarreal are in fine form this season, unbeaten in La Liga and in Europe with only three goals conceded in nine matches.
Aalborg midfielder Andreas Johansson has overcome his injury worries to be included in the 18-man squad for the trip to Spain.
Kasper Risgard, Michael Beauchamp and Jacob Nordstrom are sidelined for the Danes.